Which general indicator may suggest depressant use?

The presence of drunken behavior can be a significant indicator of depressant use. Depressants, such as alcohol and certain prescription medications, typically reduce the activity of the central nervous system, leading to effects similar to those of intoxication. This includes slurred speech, impaired coordination, and a general lack of physical and mental control, which can resemble the behavior of someone who is intoxicated.

While "on the nod" is typically associated with opioid use, and hallucinations may indicate the use of hallucinogens or stimulants, these are not general indicators of depressant use specifically. Similarly, marked reddening of the conjunctiva is often connected with marijuana use rather than depressants. Thus, the behavior reminiscent of intoxication serves as a common and recognizable sign of depressant substance influence.